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Description:Mice lacking functional TSP activity are hypertensive Yang et al. Like DR, reduced hypothalamic-pituitary axis activity is associated with resistance to age-related diseases, extended longevity and improved metabolic fitness in rodents and humans. GHRKO mice are recalcitrant to further increase in lifespan or insulin sensitivity upon DR, consistent with at least partially overlapping mechanisms of action Bonkowski et al. Subclinical hypothyroidism is associated with longevity in human centenarian studies Atzmon et al. Here, Hine et al. While H2S at high concentrations is toxic, low levels impart numerous benefits including resistance to hypoxia Blackstone and Roth, , neuroprotection Kimura and Kimura, , protection from myocardial ischemia reperfusion injury Bian et al. The publisher's final edited version of this article is available at Cell Metab See other articles in PMC that cite the published article.

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Views: 7135 Date: 2018-06-30 Favorited: 9 favorites

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